3 edition of Studies on the nature of Macrophage Cytotoxin. found in the catalog.
Studies on the nature of Macrophage Cytotoxin.
Charles Emerald Piper
Written in English
|The Physical Object|
|Pagination||viii, 55 l.|
|Number of Pages||55|
Previous studies have shown that cytotoxic activated macrophages cause inhibition of DNA synthesis, of mitochondrial respiration, and of aconitase activity in tumor target cells. An L-arginine-dependent biochemical pathway synthesizing L-citrulline and nitrite, coupled to an effector mechanism, is now shown to cause this pattern of metabolic inhibition. Murine cytotoxic activated macrophages Cited by: In the present study, similar inhibition experiments with hapten-modified targets have been used to determine the nature of the target structures recognized by the shark cytotoxic macrophage. Cold targets modified with haptens which react covalently with free amino groups on cell membranes, trini- trobenzene sulfonic acid (TNBS) and flourescein Cited by: 2.
Regarding crystalline silica-induced inflammation, in vitro studies have demonstrated that quartz as well as some other mineral dusts (i.e., crocidolite, chrysotile, coal dust) can activate rat and human alveolar macrophages to produce TNF (Driscoll et al. a; DuBois et al. ).Several of these studies have shown that TNF release occurs at quartz doses that are not cytotoxic, supporting. Recently, several studies on macrophage activation for tumor cytotoxicity provided evidence that development of macrophages with nonspecific tumoricidal activity is not the result of a single interaction between cell and activation signal, yet it requires the completion of a sequence of reactions 2–: Diana Boraschi, A. Mantovani.
Cytotoxic macrophage-released tumour necrosis factor-alpha (TNF-) as a killing mechanism for cancer cell death after cold plasma activation View the table of contents for this issue, or go to the. There is an imbalance in asthma between classically activated macrophages (M1 cells) and alternatively activated macrophages (M2 cells) in favor of the latter. MicroRNAs (miRNAs) play a critical role in regulating macrophage proliferation and differentiation and control the balance of M1 and M2 macrophage polarization, thereby controlling immune : Gavriela Feketea, Corina I Bocsan, Cristian Popescu, Mihaela Gaman, Luminita A Stanciu, Mihnea T Zdr.
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The first hint that the function of these tumour-associated macrophages (TAMs) and lymphocytes might be linked in human tumours comes from the present study by: Rowley D, Auzins I, Jenkin CR.
Further studies regarding the question of cellular immunity in mouse typhoid. Aust J Exp Biol Med Sci. Aug; 46 (4)– Ruco LP, Meltzer MS. Macrophage activation for tumor cytotoxicity: development of macrophage cytotoxic activity requires completion of a sequence of short-lived intermediary by: A dichotomy between certain functions of activated macrophages was noted in studies in which the cytotoxic and microbicidal effects were examined in parallel.
We will deal here with this dichotomy and with two related subjects: the specificity of the in vitro interaction of macrophages with tumor cells and microorganisms and the mechanisms of Cited by: 9.
Three studies have delved into the molecular mechanisms behind the metabolic reprogramming of tumour-associated macrophages, which have consequences Author: Anna Dart.
The second edition of The Macrophage is a well-presented volume running to almost pages. It contains 16 chapters by acknowledged experts, and the topics range from macrophage Cited by: The possible mechanism of normal macrophage cooperation with immunized lymphocytes in the cytotoxic killing reaction is discussed.
Results presented in this paper favour the view that immunologically specific cytophilic factor (presumptive cytophilic antibody) is involved in the macrophage-mediated cytotoxicity in the system by: CD8-positive T cells are thought to play an important role in the control of infection by human immunodeficiency virus (HIV) as a result of their cytotoxic activity and by releasing soluble.
Here Irv Weissmann and colleagues study the role for PD-1 on tumour-infiltrating macrophages in mice. The study shows that PDexpressing macrophages have limited phagocytic capabilities and that Cited by: Several studies evidenced the importance of macrophages in diseases such as asthma, atherosclerosis, rheumatoid arthritis, osteoarthritis, endometriosis, diabetes type 1 and 2, and obesity.
In asthma, Zaslona and colleagues demonstrated the role of alveolar macrophages, concluding that resident alveolar macrophages play a protective role during the early phase of allergic lung Cited by: Obesity and insulin resistance, the cardinal features of metabolic syndrome, are closely associated with a state of low-grade inflammation1,2.
In adipose tissue chronic overnutrition leads to Cited by: Macrophages are the first cells of the nascent immune system to emerge during embryonic development. Nature– ( H. Electron microscopic studies of macrophages in early. The macrophage cytotoxicity factor (MCF) binds to syngeneic and allogeneic macrophages, rendering them cytotoxic.
Cytotoxic macrophages that have destroyed target cells in tissue culture can be rendered cytotoxic again by incubation with MCF. The same culture of macrophages can destroy several target tumor cell populations.
The use of activated macrophages in the treatment of cancer has been largely ineffectual. By ‘arming’ these cells with the ability to express a therapeutic gene we Cited by: Macrophage-associated ROS production is an important feature of many physiological processes, particularly in host’s innate immunity respon However, the release of ROS includes not only nitric oxide but also superoxide-anion, hydrogen peroxide, hydroxyl radical etc.
that are associated with mitochondrial respiration Cited by: 4. Macrophages can be found as resident cells in all organs of the body, and they can be recruited to sites of inflammation.
The depletion of macrophages followed by functional studies in such macrophage-depleted animals forms a generally accepted approach to Cited by: Activated macrophages also synthesize 'lysozyme' and various hydrolytic enzymes whose degradative activities do not require Oxygen.
The activated macrophages produce a group of antimicrobials cytotoxic peptides, commonly known as " Defensin ", these Molecules are cystine- rich cationic peptides containing Amino acids : Indian Government Jobs. A study of the effects of anti-macrophage sera.
Immunology. Jan; 16 (1)– [PMC free article] Melief CJ, van der Hart M, Engelfriet CP, van Loghem JJ. Immune adherence of leucocytes and fibroblasts derived from skin, sensitized by cytotoxic leucocyte iso-antibodies and complement, to the surface of indicator cells. Vox by: 9.
Normal murine peritoneal macrophages were rendered cytotoxic against 51Cr-labelled allogeneic and syngeneic target cells by incubation with supernatant of selected cell cultures.'Active' culture supernatant was produced both by specifically sensitized cytotoxic T lymphocytes as well as by mitogen-stimulated T cells, but not by mitogen-stimulated B by: Abstract.
Macrophages are among the most versatile and multifunctional of cells. Their phagocytic ability is an essential part of the nonspecific immune defense against microorganisms, and macrophages are also required for the specific immune responses, mediated by T and B cells, to by: 9.
Spencer et al. published a protocol for THP-1 cell differentiation, showing that THP-1 cells represent a simplified model to study monocyte-macrophage polarization (Qin ). U is a pro-monocytic, human myeloid leukaemia cell line and was isolated from the histiocytic lymphoma of a 37 year old male (Sundstrom and Nilsson ).Cited by:.
CELLULAR IMMUNOL () AIIoimmune Peritoneal Macrophages as Specific Effector Cells: Characterization of Specific Macrophage Cytotoxinl C.
E. PIPER 2 AND K. L. MclvoR Department of Bacteriology and Public Health, Washington State University, Pullman, Washington Received J Specific macrophage cytotoxin (SMC) is a soluble cytotoxin detected in the Cited by: Those findings, together with the present study, suggest that CD8 + T cells enhance not only the phagocytotic capacity of macrophages but also the susceptibility of infected erythroblasts to phagocytosis through their display of by: Peritoneal Macrophage Bone Marrow Blast Macrophage Lineage Cytotoxic Effector Cell Corynebacterium Parvum These keywords were added by machine and not by the authors.
This process is experimental and the keywords may be updated as the learning algorithm by: 2.